The adipocytes manufacture liquids and proteins that compress the neighboring structures, causing a local inflammatory process of its own signs: changes in temperature, pain and changes in the aesthetic appearance of the skin known as “orange peel”. This aspect has to do with the accumulation of substances in a space that is not very extensible, with the skin as a ceiling, the floor as the muscles and walls as the fibrous partitions. In this way, the deformity caused by the thickening of the fat layer is produced which, because it can not be distributed downwards, alters the aesthetic appearance of the surface. This inflammatory process called “cellulitis” produces the accumulation of proteins and fluids in the spaces between the fat cells causing compression of the lymphatic vessels, veins and the adipocytes themselves, preventing normal circulation. We believe that cellulite represents, barely, “the tip of the iceberg”, since it is the part of the problem that is seen: in reality, it is the external expression of a sum of factors that are in the depth and that are the real causes of the orange skin. We consider that the problem of venous microcirculation should be treated, identifying it as the main generator of toxin accumulation, and fluid in the inter and extracellular space, which after a while will generate an inflammatory reaction that will culminate in the formation of fibrous septa, which they will give the skin appearance to the skin. We consider that it should be treated jointly, considering the 4 big legs of the treatment against cellulite, healthy diet, aerobic exercise, mesotherapy and lymphatic drainage. It should be taken into account that more than 70% of women have some degree of cellulite, so it is not considered as a disease, but as a normal process that can occur in women. That is why, in case of having some degree of cellulite, you can decrease that grade, even make it disappear in the lower grades, but it will never be cured, that is, after leaving the treatment, cellulite may return. What we will achieve with the treatment will be to stop and reverse this process.